Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Autor: Maria Antonieta Ramírez-Morales, Anastasia E. Goldt, Polina M. Kalachikova, Javier A. Ramirez B., Masashi Suzuki, Alexey N. Zhigach, Asma Ben Salah, Liliya I. Shurygina, Sergey D. Shandakov, Timofei Zatsepin, Dmitry V. Krasnikov, Toru Maekawa, Evgeny N. Nikolaev, Albert G. Nasibulin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nanomaterials, Vol 12, Iss 16, p 2869 (2022)
Druh dokumentu: article
ISSN: 2079-4991
DOI: 10.3390/nano12162869
Popis: Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.
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