| Autor: |
Emilia Gigliotta, Federica Plano, Giusy Corsale, Anna Maria Corsale, Cristina Aquilina, Maria Speciale, Andrea Rizzuto, Enrica Antonia Martino, Dario Leotta, Antonio Giovanni Solimando, Roberto Ria, Massimo Gentile, Sergio Siragusa, Cirino Botta |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2162-3619 |
| DOI: |
10.1186/s40164-024-00547-x |
| Popis: |
Abstract Multiple myeloma (MM) is a hematologic malignancy characterized by abnormal plasma cell proliferation in the bone marrow. Recent advancements in anti-CD38 monoclonal antibody therapies, such as daratumumab and isatuximab, have significantly improved MM patient survival. However, the lack of predictive factors of response to these therapies remains a challenge. Notably, anti-CD38 antibodies can interfere with laboratory tests, complicating response assessment. We conducted a retrospective study to evaluate the association between the appearance of positive IgGk (therapeutic antibody) on immunofixation/immunosubtraction (IF) and clinical parameters in 87 non-IgGk MM patients treated with anti-CD38 therapy. Positive IgGk IF was observed in 42 patients after a median of three treatment courses. Patients with positive IgGk IF had higher rates of complete/very good partial responses (p = 0.03) and improved progression-free survival (median not reached vs. 21.83 months, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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