| Autor: |
Massimo Marano, Jessica Rosati, Alessandro Magliozzi, Alessia Casamassa, Alessia Rappa, Gabriele Sergi, Miriam Iannizzotto, Ziv Yekutieli, Angelo Luigi Vescovi, Vincenzo Di Lazzaro |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Neurobiology of Sleep and Circadian Rhythms, Vol 14, Iss , Pp 100094- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2451-9944 |
| DOI: |
10.1016/j.nbscr.2023.100094 |
| Popis: |
Circadian rhythm impairment may play a role in Parkinson's disease (PD) pathophysiology. Recent literature associated circadian rhythm features to the risk of developing Parkinson and to its progression through stages. The association between the chronotype and the phenotype should be verified on a clinical and biological point of view. Herein we investigate the chronotype of a sample of 50 PD patients with the Morningness Eveningness Questionnaire and monitor their daily activity with a motion sensor embedded in a smartphone. Fibroblasts were collected from PD patients (n = 5) and from sex/age matched controls (n = 3) and tested for the circadian expression of clock genes (CLOCK, BMAL1, PER1, CRY1), and for cell morphology, proliferation, and death. Our results show an association between the chronotype and the PD phenotype. The most representative clinical chronotypes were “moderate morning” (56%), the “intermediate” (24%) and, in a minor part, the “definite morning” (16%). They differed for axial motor impairment, presence of motor fluctuations and quality of life (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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