Saliva as a reliable diagnostic tool during the coronavirus disease times: A focused review
| Autor: | Sarita Shaukari, Souren Bellam, K Raghu Nandan, Revathi Peddu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Indian Journal of Dental Sciences, Vol 13, Iss 4, Pp 294-297 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0976-4003 2231-2293 |
| DOI: | 10.4103/IJDS.IJDS_206_20 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also currently known as CoV disease 2019 (COVID-19), has created a global health upheaval. The saliva of an infected person serves as a source for the transmission of CoV. The angiotensin-converting enzyme-2 receptors serve as the host receptor cells for CoV which is expressed in high numbers in salivary glands, oral mucosa, and gingiva. The salivary gland is a potential reservoir for COVID-19 even in asymptomatic but infected carriers. This knowledge could be used to employ salivary sampling as a noninvasive diagnostic method. IgA, IgM antibodies detected in self-collected saliva show more stability than RNA and may aid in the identification of asymptomatic patients. Saliva shows high sensitivity and specificity in the diagnosis of COVID-19 with >90% concordance reported between the saliva and nasopharyngeal swabs. Standardization with respect to sample collection, storage, and transport media can help in validation of diagnostic application of salivary-based testing. |
| Databáze: | Directory of Open Access Journals |
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