Activation of BDNF-mediated PKA signaling in the ventral hippocampus by Capsosiphon fulvescens glycoproteins alleviates depressive-like behavior in aged rats

Autor: Jeong Hwan Oh, Taek-Jeong Nam, Youn Hee Choi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Functional Foods, Vol 73, Iss , Pp 104112- (2020)
Druh dokumentu: article
ISSN: 1756-4646
21364397
DOI: 10.1016/j.jff.2020.104112
Popis: Aging is associated with an increased risk of emotional disorders such as depression. In this study, effects of Capsosiphon fulvescens hydrophilic glycoproteins (Cf-hGP) on depressive-like behavior in aged rats were investigated. Oral administration of Cf-hGP (15 mg/kg/day; 4 weeks) attenuated immobility time of aged rats in forced swimming test by increasing expression of mature brain-derived neurotrophic factor (BDNF) in the ventral hippocampus. Cf-hGP-induced BDNF-mediated activation of extracellular signal-regulated kinase (ERK)1/2 increased cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) phosphorylation, which upregulated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) GluA1 phosphorylation at serine 845. The activation of BDNF-mediated PKA signaling by Cf-hGP also attenuated endoplasmic reticulum (ER) stress in the ventral hippocampus. AMPAR blockade or PKA inhibition abolished the Cf-hGP-induced decrease in immobility time. These findings suggest that BDNF-mediated cAMP/PKA signaling in the ventral hippocampus contributes to antidepressant effects of Cf-hGP by regulating AMPAR GluA1 phosphorylation and ER stress.
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