| Autor: |
Chris Gale, Marian Knight, Kirsty Le Doare, Erica M Lokken, Laura A Magee, Peter von Dadelszen, Nathalie Broutet, Emily R Smith, Deborah Money, Stephanie Jones, Olof Stephansson, Lesley Regan, Fouzia Farooq, Christoph Lees, Julia Townson, Sami L Gottlieb, Jonas Söderling, Jorge Carrillo, Anna Thorson, Marleen Temmerman, Joyce Were, Edward Mullins, Ajay Reddy, Valerie J Flaherman, Clayton Onyango, Shabir A Madhi, Antonio Lanzone, Liona C Poon, Alice Panchaud, Musa Sekikubo, Eduard Gratacos, Renate Strehlau, Cande V. Ananth, Jorge E Tolosa, Justin S Brandt, Jennifer Hill, Erich Cosmi, Lauren Hookham, Raigam Jafet Martínez-Portilla, Francesca Crovetto, Fatima Crispi, Robert Mboizi, Jean B Nachega, Silvia Visentin, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A Tippett Barr, Elisa Bevilacqua, Irene Fernández Buhigas, Rebecca Clifton, Jeanne Conry, Camille Delgado-López, Hema Divakar, Amanda J Driscoll, Guillaume Favre, Maria M Gil, Olivia Hernandez, Erkan Kalafat, Sammy Khagayi, Karen Kotloff, Ethan Litman, Valentina Laurita Longo, Elizabeth M McClure, Tori D Metz, Emily S Miller, Sakita Moungmaithong, Marta C Nunes, Dickens Onyango, Daniel Raiten, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Miguel Valencia-Prado, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M Tielsch, Eduard Langenegger, Nadia A. Sam-Agudu, Onesmus W. Gachuno, Denis M. Mukwege, Richard Omore, Gregory Ouma, Kephas Otieno, Zacchaeus Abaja Were, Pinar Birol İlter, Federica Meli, Giulia Bonanni, Federica Romanzi, Eleonora Torcia, Chiara di Ilio, Haylea Sweat Patrick, Vuyelwa Baba, Mary Adam, Philiswa Mlandu, Yasmin Adam |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BMJ Global Health, Vol 8, Iss 1 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2059-7908 |
| DOI: |
10.1136/bmjgh-2022-009495 |
| Popis: |
Introduction Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.Methods We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.Results We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.Conclusions This analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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