The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults

Autor: Ahmed Azzam, Heba Khaled, Neveen Refaey, Shorouk Mohsen, Ola Ali El-Emam, Nada Dawood, Hebatalla A. Ahmed, Omar A. Soliman, Sana Mostafa, Heba Ramadan, Maha Mosa, Amora Omar Ibrahim Elmowafy, Shimaa Mohamed Abdou Rizk, Ahmed Zaki, Mostafa Hussien, Ameer Ahmed, Ahmad Ashraf Ezzat, Fatma E. Hassan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Virology Journal, Vol 21, Iss 1, Pp 1-18 (2024)
Druh dokumentu: article
ISSN: 1743-422X
DOI: 10.1186/s12985-024-02284-3
Popis: Abstract Background Previous meta-analyses estimating the prevalence of the post-COVID-19 condition (PCC) were confounded by the lack of negative control groups. This may result in an overestimation of the prevalence of those experiencing PCC, as these symptoms are non-specific and common in the general population. In this study, we aimed to compare the burden of persistent symptoms among COVID-19 survivors relative to COVID-19-negative controls. Methods A systematic literature search was conducted using the following databases (PubMed, Web of Science, and Scopus) until July 2023 for comparative studies that examined the prevalence of persistent symptoms in COVID-19 survivors. Given that many of the symptoms among COVID-19 survivors overlap with post-hospitalization syndrome and post-intensive care syndrome, we included studies that compare the prevalence of persistent symptoms in hospitalized COVID-19 patients relative to non-COVID-19 hospitalized patients and in non-hospitalized COVID-19 patients relative to healthy controls that reported outcomes after at least 3 months since infection. The results of the meta-analysis were reported as odds ratios with a 95% confidence interval based on the random effects model. Results Twenty articles were included in this study. Our analysis of symptomatology in non-hospitalized COVID-19 patients compared to negative controls revealed that the majority of symptoms examined were not related to COVID-19 infection and appeared equally prevalent in both cohorts. However, non-COVID-19 hospitalized patients had higher odds of occurrence of certain symptoms like anosmia, ageusia, fatigue, dyspnea, and brain fog (P
Databáze: Directory of Open Access Journals
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