| Autor: |
Etheldreda Nakimuli-Mpungu, PhD, Seggane Musisi, ProfFRCP[C], Kizito Wamala, MSc, James Okello, PhD, Sheila Ndyanabangi, MPH, Josephine Birungi, MPH, Mastula Nanfuka, MPH, Micheal Etukoit, MPH, Chrispus Mayora, MPH, Freddie Ssengooba, PhD, Ramin Mojtabai, ProfPhD, Jean B Nachega, ProfPhD, Ofir Harari, PhD, Edward J Mills, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
The Lancet Global Health, Vol 8, Iss 3, Pp e387-e398 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-109X |
| DOI: |
10.1016/S2214-109X(19)30548-0 |
| Popis: |
Summary: Background: WHO recommends the use of psychological interventions as first-line treatment for depression in low-income and middle-income countries. However, evaluations of the effectiveness and cost-effectiveness of such interventions among people with HIV are scarce. Our aim was to establish the effectiveness of group support psychotherapy (GSP) delivered by lay health workers for depression treatment among people living with HIV in a rural area of Uganda on a large scale. Methods: In this cluster-randomised trial, we included 30 health centres offering HIV care. These were randomly assigned to deliver either GSP or group HIV education (GHE). Randomisation, in a ratio of 1:1, was achieved by health centre managers separately picking a paper containing the intervention allocation from a basket. Participants were people living with HIV, aged 19 years and older, with mild to moderate major depression assessed with the Mini International Neuropsychiatric Interview depression module, taking antiretroviral therapy, and antidepressant-naive. Group sessions were led by trained lay health workers once a week for 8 weeks. The primary outcomes were the proportion of participants with major depression and function scores at 6 months post-treatment, analysed by intention to treat by means of multilevel random effect regression analyses adjusting for clustering in health centres. This trial is registered with the Pan African Clinical Trials Registry, PACTR201608001738234. Findings: Between Sept 13 and Dec 15, 2016, we assessed 1473 individuals, of whom 1140 were recruited from health centres offering GSP (n=578 [51%]) or GHE (n=562 [49%]). Two ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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