Activity of Ca(2+),Mg(2+)-ATPase of sarcoplasmic reticulum and contraction strength of the frog skeletal muscles under the effect of organophosphorus insecticides

Autor: D. M. Nozdrenko, L. V. Korchinska, V. M. Soroca
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: The Ukrainian Biochemical Journal, Vol 87, Iss 4, Pp 63-69 (2015)
Druh dokumentu: article
ISSN: 2409-4943
2413-5003
DOI: 10.15407/ubj87.04.063
Popis: The results of an experimental study of organo­phosphorus insecticides, including pirimiphosmethyl, diazinon and chlorpyrifos caused a decline of the contraction properties in m. tibialis anterior fiber bundles of Rana temporaria, as well as sarcoplasmic reticulum Ca2+,Mg2+-ATPase enzymatic activity reduction are outlined in this paper. Concentration-dependent strengths response diminishing in isolated skeletal muscle fiber bundles as a result of non-cholinergic influence of organophosphorus insecticides were found. A decrease of Ca2+,Mg2+-ATPase enzymatic activity in sarcoplasmic reticulum was observed after administration of each insecticide. The most significant inhibition of this enzyme was observed when using chlorpyrifos.
Databáze: Directory of Open Access Journals
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