POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS

Autor:	A. V. Sosnov, S. V. Sadovnikov, F. M. Semchenko, K. A. Rufanov, V. N. Tohmahchi, A. A. Sosnova, I. A. Tyurin
Jazyk:	ruština
Rok vydání:	2019
Předmět:	severe and moderate pain potent non-narcotic analgesic lead compounds biotargets of nervous system ion channel blocker tetrodotoxin Pharmaceutical industry HD9665-9675
Zdroj:	Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 196-206 (2019)
Druh dokumentu:	article
ISSN:	2305-2066 2658-5049
Popis:	The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmaceuticals. Their application is very important as an alternative to opiates. However, the actual number of drug candidates is very limited. As a result of the authors analysis one of the most potent non-narcotic analgesics (PNS neurons sodium channel blocker) - Tetrodotoxin (TTX) was recognized as the most promising. Currently FSUE «GosZMP» conducting preclinical studies of injectable preparation of TTX.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/20e25fd954fa45c99e6f7c010cf1db9a Zobrazit plný text záznamu View record in DOAJ