Docosahexaenoic acid–mediated, targeted and sustained brain delivery of curcumin microemulsion

Autor:	Rajshree L. Shinde, Padma V. Devarajan
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	brain targeting curcumin microemulsion docosahexaenoic acid u-87 mg human glioblastoma cell line intranasal intravenous Therapeutics. Pharmacology RM1-950
Zdroj:	Drug Delivery, Vol 24, Iss 1, Pp 152-161 (2017)
Druh dokumentu:	article
ISSN:	1071-7544 1521-0464 10717544
DOI:	10.1080/10717544.2016.1233593
Popis:	We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal administration exhibited negative zeta potential, globule size 66-fold(intranasal) and >21–fold (intravenous) the IC50 value in the U-87MG cell line suggests great promise of CUR DHA ME for therapy of brain cancer by both routes.
Databáze:	Directory of Open Access Journals
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