Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy

Autor: Jifeng Yu, Bangguo Zhou, Shen Zhang, Haohao Yin, Liping Sun, Yinying Pu, Boyang Zhou, Yikang Sun, Xiaolong Li, Yan Fang, Lifan Wang, Chongke Zhao, Dou Du, Yan Zhang, Huixiong Xu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35580-z
Popis: Recently, strategies based on the integration of nanotechnology with microbial carriers have been proposed for cancer therapy. Here the authors report the design of an ultrasound-controlled CRISPR/Cas9 gene editing system for IDO1 silencing compounded with the probiotic Lactobacillus rhamnosus GG, showing the induction of anti-tumor immune responses in preclinical cancer models.
Databáze: Directory of Open Access Journals