A Novel Pyroptosis-Based Prognostic Model Correlated with the Parainflammatory Immune Microenvironment of Pancreatic Cancer

Autor:	Kong-kong Wei, Zhi-xing Du, Jun-ge Deng, Jin-wei Yang, Hao Chen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Immunologic diseases. Allergy RC581-607
Zdroj:	Journal of Immunology Research, Vol 2023 (2023)
Druh dokumentu:	article
ISSN:	2314-7156
DOI:	10.1155/2023/8776892
Popis:	Background. Pyroptosis has a dual function in malignant tumor progression and management. The action of pyroptosis-related genes (PRGs) in pancreatic cancer (PC), however, remains uncertain. Methods. Differential expression analyses of 57 PRGs were conducted in the TCGA TARGET GTEx dataset. The candidate genes were determined using LASSO Cox regression and random forest analyses. A risk model was developed with the TCGA dataset and validated with the ICGC dataset. Results. Three prognosis-related PRGs (BAK1, GSDMC, and IL18) were chosen to create a risk model. High-risk patients from the TCGA and ICGC cohorts had an unfavorable overall survival (all p
Databáze:	Directory of Open Access Journals
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