Structural Determinants in the Calcitonin Receptor-Like Receptor (Crlr) Important for Cgrp and Adrenomedullin (Am) Receptor Function of Crlr/Receptor-Activity-Modifying Protein (Ramp) 1 and Crlr/Ramp2 Heterodimers

Autor: W. Born, K. Leuthauser, R. Gujer, R. Muff, J.A. Fischer
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Zdroj: The Scientific World Journal, Vol 1, Pp 8-8 (2001)
Druh dokumentu: article
ISSN: 1537-744X
DOI: 10.1100/tsw.2001.405
Popis: Cell surface protein cross-linking, coimmmunoprecipitation, and confocal microscopy identified CRLR/RAMP1-, CRLR/RAMP2-, and calcitonin receptor isotype 2 (CTR2)/RAMP1 heterodimers as CGRP-, AM-, and CGRP/amylin receptors, linked to cAMP production. Along these lines, effects of structural alterations in the N-terminal extracellular domain of the human CRLR on cell surface expression as well as the association with RAMP and CGRP or AM have been investigated.
Databáze: Directory of Open Access Journals
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