Experimental cholesteatoma: a comparison between spontaneous and induced models

Autor: Felipe da Costa Huve, Jefferson André Bauer, Fábio André Selaimen, Maurício Noschang Lopes da Silva, Sady Selaimen da Costa
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Brazilian Journal of Otorhinolaryngology, Vol 89, Iss 1, Pp 73-78 (2023)
Druh dokumentu: article
ISSN: 1808-8694
DOI: 10.1016/j.bjorl.2021.09.003
Popis: Objective: To compare the incidence and the histopathological aspect of spontaneous and two induced Mongolian gerbils’ models of cholesteatoma: External Auditory Canal (EAC) obliteration model and the Auditory Tube (AT) cauterization model. Methods: Fifty-four ears of 27 animals were divided into EAC obliteration, AT cauterization, and control groups and histologically assessed for cholesteatoma incidence and classification at intervals of 2, 4, 8, and 16 weeks. Results: Cholesteatoma was diagnosed in 30 of the 53 ears evaluated with a significantly higher incidence in groups that received some type of intervention (p
Databáze: Directory of Open Access Journals