Contribution of phosphorus and PTH to the development of cardiac hypertrophy and fibrosis in an experimental model of chronic renal failure

Autor: Laura Martínez-Arias, Sara Panizo-García, Julia Martín-Vírgala, Beatriz Martín-Carro, Sara Fernández-Villabrille, Noelia Avello-Llano, Diego Miguel-Fernández, María Piedad Ruíz Torres, Jorge B. Cannata-Andía, Natalia Carrillo-López, Manuel Naves-Díaz
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nefrología (English Edition), Vol 41, Iss 6, Pp 640-651 (2021)
Druh dokumentu: article
ISSN: 2013-2514
DOI: 10.1016/j.nefroe.2021.12.004
Popis: Background and objective: Adequate serum phosphorus levels in patients with chronic kidney disease is essential for their clinical management. However, the control of hyperphosphatemia is difficult because is normally associated with increases in serum PTH. In the present study, the effects of hyperphosphatemia, in the presence of elevated and normal PTH, on cardiac inflammation, hypertrophy and fibrosis in an experimental renal failure model were analyzed. Materials and methods: 4 groups of rats were formed. Two groups underwent total parathyroidectomy (PTx). Rats with Ca
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