Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus

Autor: Bai Hui Chen, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Bich Na Shin, Ji Hyeon Ahn, Seok Joon Hwang, Bing Chun Yan, Hyun Jin Tae, Jae Chul Lee, Eun Joo Bae, Yun Lyul Lee, Jong Dai Kim, Moo-Ho Won, Il Jun Kang
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Alzheimer′s disease
amyloid-β
astrocytes
Ca 2+
calcilytic
calcium-sensing receptor
nitromemantine
NPS 2143
α7-nicotinic acetylcholine receptor
nerve regeneration
spinal cord injury
surgical decompression
tumor necrosis factor α
cell apoptosis
neurological function
neural regeneration
contusion
Nogo-A
axon growth
immunohistochemistry
fluorescent quantitative PCR
Schwann cells
cell transplantation
edaravone
motor function
electrophysiological function
electroacupuncture
intervertebral disc
blood circulation
inflammation
neuroprotection
neurons
NSFC grants
astrocytoma
mice
immunodeficiency (BALB/c) mice
Notch
nestin
glial fibrillary acidic protein
CD133
spinal cord
brain
MRI
earthquake
peripheral nerve injury
LSUHSC score
compartment syndrome
surgery therapy
physiotherapy
nerve decompression
brachial plexus injury
human amniotic epithelial cells
forepaw function
stress relaxation
creep
viscoelasticity
injection injury
cyclosporine A
penicillin G potassium
Wallerian degeneration
neuroelectrophysiology
Oenanthe javanica extract
cell proliferation
neuroblast differentiation
brain-derived neurotrophic factor
vascular endothelial growth factor
rat
Neurology. Diseases of the nervous system
RC346-429
Zdroj: Neural Regeneration Research, Vol 10, Iss 2, Pp 271-276 (2015)
Druh dokumentu: article
ISSN: 1673-5374
DOI: 10.4103/1673-5374.152382
Popis: Oenanthe javanica is an aquatic perennial herb that belongs to the Oenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glutamate-induced neurotoxicity. However, few studies regarding effects of Oenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract of Oenanthe javanica on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 (an endogenous marker for cell proliferation) and doublecortin (a marker for neuroblast). Our results showed that Oenanthe javanica extract significantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was significantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not find that vascular endothelial growth factor expression was increased in the Oenanthe javanica extract-treated group compared with the control group. These results indicate that Oenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-derived neurotrophic factor immunoreactivity in the rat dentate gyrus.
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