Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids

Autor:	Syed Nasir Abbas Bukhari, Hasan Ejaz, Mervat A. Elsherif, Nenad Janković
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	dihydrouracil Biginelli hybrid synthesis tetrahydropyrimidine m-chloroperbenzoic acid Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 9, p 2939 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27092939
Popis:	Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%).
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d20a03d8ed63427d942e7b5c01f47835 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.