Symptomatic Steno-Occlusion in Patients with Acute Cerebral Infarction: Prevalence, Distribution, and Functional Outcome

Autor: Jihoon Kang, Tai Hwan Park, Kyung Bok Lee, Jong-Moo Park, Youngchai Ko, Soo Joo Lee, Keun-Sik Hong, Yong-Jin Cho, Ji Sung Lee, Juneyoung Lee, Byung-Chul Lee, Kyung-Ho Yu, Dae-Hyun Kim, Jae-Kwan Cha, Jun Lee, Myung Suk Jang, Moon-Ku Han, Hee-Joon Bae
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Stroke, Vol 16, Iss 1, Pp 36-43 (2014)
Druh dokumentu: article
ISSN: 2287-6391
2287-6405
DOI: 10.5853/jos.2014.16.1.36
Popis: Background and PurposeSymptomatic steno-occlusion (SYSO) in acute ischemic stroke has a significant impact on treatment options and prognosis. However, the prevalence, distribution, clinical characteristics, and outcome of SYSO are not well known.MethodsWe retrospectively identified 3,451 patients hospitalized because of ischemic stroke within 24 hours of symptom onset at 9 stroke centers in South Korea. Patients who did not undergo magnetic resonance imaging were excluded. SYSO was defined as stenosis or occlusion of cerebral arteries with relevant ischemic lesions in the corresponding arterial territory. The number, location, and severity of SYSOs and their effects on functional outcome were analyzed.ResultsIn total, 1,929 of 3,057 subjects (63.1%) had SYSO. The most frequently affected vessels were the middle cerebral artery (34.6%), extracranial internal carotid artery (14%), vertebral artery (12.4%), and basilar artery (8.7%). SYSO predicted poor outcome on the modified Rankin Scale 3-6 (odds ratio, 1.77; 95% confidence interval, 1.46-2.15) with adjustments. Involvement of 2 or more vessels was observed in 30.6% of patients with SYSO and independently increased the risk of poor outcome (odds ratio, 2.76; 95% confidence interval, 2.12-3.59). The severity of SYSO was associated with outcome and showed a significant dose-response trend (P
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