| Autor: |
Jong-Hwa Kim, Jihye Baek, Soonok Sa, Jiwon Park, Minji Kih, Wonyong Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 85, Iss , Pp 104650- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2021.104650 |
| Popis: |
Interest in the beneficial effects of fructo-oligosaccharides (FOSs), a prebiotic supplement, on human health is increasing. The effects of 1-kestose, a key component of FOS, have been studied; however, the effects of kestose-enriched FOS on atopic dermatitis (AD) have not been investigated. This study aimed to examine the mechanism through which kestose-enriched FOS alleviated AD in OVA-sensitised Balb/c mice and compared the effects with those of normal FOS. Kestose-enriched FOS increased butyric and propionic acid levels in faeces to a significantly greater extent than did normal FOS. This increase was associated with increased abundance of Lactobacillus and Alistipes and decreased abundance of Prevotella. Furthermore, kestose-enriched FOS markedly decreased IgE levels and the counts of regulatory T cell-mediated T helper cell type 2, mast cells, and eosinophils. Thus, kestose-enriched FOS modulated the gut-skin axis by altering the intestinal microbiome and immune response, indicating its potential as a supplement for AD mitigation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect