| Autor: |
Michael Malek-Ahmadi, Thomas G Beach, Edward Zamrini, Charles H Adler, Marwan N Sabbagh, Holly A Shill, Sandra A Jacobson, Christine M Belden, Richard J Caselli, Brian K Woodruff, Steven Z Rapscak, Geoffrey L Ahern, Jiong Shi, John N Caviness, Erika Driver-Dunckley, Shyamal H Mehta, David R Shprecher, Bryan M Spann, Pierre Tariot, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony Intorcia, Michael J Glass, Jessica E Walker, Michael Callan, Jasmine Curry, Brett Cutler, Javon Oliver, Richard Arce, Douglas G Walker, Lih-Fen Lue, Geidy E Serrano, Lucia I Sue, Kewei Chen, Eric M Reiman |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 14, Iss 6, p e0217566 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0217566 |
| Popis: |
BackgroundNeuropathology has demonstrated a high rate of comorbid pathology in dementia due to Alzheimer's disease (ADD). The most common major comorbidity is Lewy body disease (LBD), either as dementia with Lewy bodies (AD-DLB) or Alzheimer's disease with Lewy bodies (AD-LB), the latter representing subjects with ADD and LBD not meeting neuropathological distribution and density thresholds for DLB. Although it has been established that ADD subjects with undifferentiated LBD have a more rapid cognitive decline than those with ADD alone, it is still unknown whether AD-LB subjects, who represent the majority of LBD and approximately one-third of all those with ADD, have a different clinical course.MethodsSubjects with dementia included those with "pure" ADD (n = 137), AD-DLB (n = 64) and AD-LB (n = 114), all with two or more complete Mini Mental State Examinations (MMSE) and a full neuropathological examination.ResultsLinear mixed models assessing MMSE change showed that the AD-LB group had significantly greater decline compared to the ADD group (β = -0.69, 95% CI: -1.05, -0.33, pConclusionsThe probable cause of LBD clinical detection failure is the lack of a sufficient set of characteristic core clinical features. Core DLB clinical features were not more common in AD-LB as compared to ADD. Clinical identification of ADD with LBD would allow stratified analyses of ADD clinical trials, potentially improving the probability of trial success. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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