The Role of Bispecific Antibodies in Non-Hodgkin’s Lymphoma: From Structure to Prospective Clinical Use

Autor:	Rita Tavarozzi, Enrica Manzato
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	bispecific antibody bispecific T-cell engager non-Hodgkin’s lymphoma blinatumomab Immunologic diseases. Allergy RC581-607
Zdroj:	Antibodies, Vol 11, Iss 1, p 16 (2022)
Druh dokumentu:	article
ISSN:	2073-4468
DOI:	10.3390/antib11010016
Popis:	Bispecific antibodies (bsAbs) are molecules that simultaneously bind two different antigens (Ags). bsAbs represent a very active field in tumor immunotherapy with more than one hundred molecules currently being tested. More specifically, they have elicited a great interest in the setting of non-Hodgkin’s lymphoma (NHLs), where they could represent a viable option for more fragile patients or those resistant to other conventional therapies. This review aims to give a brief overview of the different available bsAb formats and their mechanisms of action, pinpointing the differences between IgG-like and non-IgG-like classes and will then focus on those in advanced clinical development for NHLs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2084a5ddf5944349bded450d9bcc013b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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