| Autor: |
Tímea Tünde Takács, Ádám József Berki, Péter Pál Böjti, Rita Stang, Pablo Antonio Fritz-Reunes, Luiz Schnekenberg, Timo Siepmann, Alexandra Pintér, Szabolcs Szatmári, Dániel Bereczki, Bence Gunda |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 18, Iss 3 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| Popis: |
Background Acute ischemic stroke (AIS) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection (COVID-19), but the prognosis of these patients is poorly understood. Purpose To explore the impact of COVID-19 on neurological outcomes in AIS patients. Methods A comparative retrospective cohort study was conducted in 32 consecutive AIS patients with and 51 without COVID-19 between the 1st of March 2020 and 1st of May 2021. The evaluation was based on a detailed chart review for demographic data, medical history, stroke severity, cranial and vessel imaging results, laboratory parameters, COVID-19 severity, hospitalization time, in-hospital mortality, and functional deficits at discharge (modified Rankin Scale, mRS). Results COVID-19 AIS patients showed tendency to worse initial neurological deficit (NIHSS 9 (3–13) vs. 4 (2–10); p = 0.06), higher rate of large vessel occlusion (LVO; 13/32 vs. 14/51; p = 0.21), had prolonged hospitalization (19.4 ± 17.7 vs. 9.7 ± 7 days; p = 0.003), had lower chance of functional independence (mRS≤2) (12/32 vs. 32/51; p = 0.02) and showed higher in-hospital mortality (10/32 vs. 6/51; p = 0.02). In COVID-19 AIS patients, LVO was more common with COVID-19 pneumonia than without (55.6% vs. 23.1%; p = 0.139). Conclusion COVID-19-related AIS carries a worse prognosis. COVID-19 with pneumonia seems to be associated with a higher rate of LVO. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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