Efficacy and Safety of Lamotrigine Adjunctive Therapy in Lennox-Gastaut Syndrome

Autor:	Hui Jin Shin, Ara Ko, Se Hee Kim, Joon Soo Lee, Heung Dong Kim, Hoon-Chul Kang
Jazyk:	English<br />Korean
Rok vydání:	2023
Předmět:	lennox gastaut syndrome lamotrigine anticonvulsants Internal medicine RC31-1245 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Child Neurology, Vol 31, Iss 2, Pp 91-96 (2023)
Druh dokumentu:	article
ISSN:	2635-909X 2635-9103
DOI:	10.26815/acn.2022.00437
Popis:	Purpose Lamotrigine (LTG) is often used as adjunctive therapy in Lennox-Gastaut syndrome (LGS); however, it may worsen myoclonic and atypical absence seizures in LGS patients. This study reviewed the overall efficacy and safety of LTG in children with LGS. Methods This retrospective study included 38 patients (aged 50% in 47.4% of patients (18/38). After 6 months, 20 patients (20/36, 55.6%) showed a favorable response. After 12 months, five patients (5/11, 45.5%) responded to treatment. Three patients showed myoclonic seizures at the start of treatment and >50% amelioration in seizure frequency at the 3- and 6-month follow-up visits. Conclusion This study reaffirms the efficacy and safety of LTG in children with LGS. Therefore, LTG is strongly recommended as an adjunctive therapy for children with LGS.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/208445f513a94b3a9aac7a724a86ae1a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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