The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs

Autor:	Martha L Slattery, Lila E Mullany, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Jennifer S Herrick
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Informatics, Vol 17 (2018)
Druh dokumentu:	article
ISSN:	1176-9351 11769351
DOI:	10.1177/1176935118766522
Popis:	Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation and apoptosis. We examined associations of differential gene and microRNA (miRNA) expression between carcinoma and paired normal mucosa for 241 genes in the KEGG-identified MAPK-signaling pathway among 217 colorectal cancer (CRC) cases. Gene expression data (RNA-Seq) and miRNA expression data (Agilent Human miRNA Microarray V19.0; Agilent Technologies Inc., Santa Clara, CA, USA) were analyzed. We first identified genes most strongly associated with CRC using a fold change (FC) of >1.50 or
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/207ecfcd04d94433a46dc325a254eaf3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF