| Autor: |
David W. Cleary, Denise E. Morris, Rebecca A. Anderson, Jessica Jones, Ahmed Ghazi Alattraqchi, Nor Iza A. Rahman, Salwani Ismail, Mohd Sayuti Razali, Rahmah Mohd Amin, Aniza Abd Aziz, Nor Kamaruzaman Esa, Salman Amiruddin, Ching Hoong Chew, Hafis Simin, Ramle Abdullah, Chew Chieng Yeo, Stuart C. Clarke |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-11 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2055-5008 |
| DOI: |
10.1038/s41522-020-00173-5 |
| Popis: |
Abstract Much microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples of Malaysia. A total of 130 participants were recruited from two sites in the north-eastern state of Terengganu in Peninsular Malaysia. Using 16S rRNA sequencing, the nasal microbiome was significantly more diverse in those aged 5–17 years compared to 50+ years (p = 0.023) and clustered by age (PERMANOVA analysis of the Bray–Curtis distance, p = 0.001). Hierarchical clustering of Bray–Curtis dissimilarity scores revealed six microbiome clusters. The largest cluster (n = 28; 35.4%) had a marked abundance of Corynebacterium. In the oral microbiomes Streptococcus, Neisseria and Haemophilus were dominant. Using conventional microbiology, high levels of Staphylococcus aureus carriage were observed, particularly in the 18–65 age group (n = 17/36; 47.2% 95% CI: 30.9–63.5). The highest carriage of pneumococci was in the |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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