A novel biomarker renalase and its relationship with its substrates in schizophrenia
| Autor: | Catak Zekiye, Kocdemir Esra, Ugur Kader, Yardim Meltem, Sahin İbrahim, Kaya Hilal, Suleyman Aydin |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 38, Iss 3, Pp 299-305 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| Popis: | Background: Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Therefore, the current study aimed to evaluate the renalase and CA levels in the serum of patients with schizophrenia. Methods: The study was conducted with thirty-three schizophrenia patients and an ageand gender-matched group of thirty-one controls. Renalase and CA levels were measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Renalase levels were significantly lower in the schizophrenia patients than in the control group (p |
| Databáze: | Directory of Open Access Journals |
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