| Autor: |
Nicole S Erler, Robert J de Knegt, Jordan J Feld, Bettina E Hansen, Harry L A Janssen, Adriaan J van der Meer, Christoph Welsch, Stefan Zeuzem, Amy Puenpatom, Thomas Vanwolleghem, Robert A de Man, Lisette A P Krassenburg, Raoel Maan, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2054-4774 |
| DOI: |
10.1136/bmjgast-2023-001209 |
| Popis: |
Background and aims Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasive Fibrosis-4 (FIB-4) index in patients with chronic HCV and early disease.Methods and results Patients diagnosed with chronic HCV and FIB-4 3.25 during follow-up. Survival analyses were used to assess time to FIB-4 >3.25.In total, 4286 patients were followed for a median of 5.0 (IQR 1.7–9.4) years, during which 41 071 FIB-4 measurements were collected. At baseline, median age was 47 (IQR 39–55) years, 2529 (59.0%) were male, and 2787 (65.0%) patients had a FIB-4 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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