Autor: |
R. Yuvashri, Era Dravida Thendral, D. Reuben Jonathan, A. Anish Fathima, K. Laavanya, G. Usha |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Chemical Physics Impact, Vol 9, Iss , Pp 100663- (2024) |
Druh dokumentu: |
article |
ISSN: |
2667-0224 |
DOI: |
10.1016/j.chphi.2024.100663 |
Popis: |
In this work, a series of curcumin derivatives have been synthesized using Claisen Schmidt condensation reaction & Schotten-Baumann reaction, and they were screened through in-silico and in-vitro analysis to determine their capacity as a potential agent against breast cancer. Molecular docking reveals that the compounds are in good fit in the active site region of the target protein. Anti-cancer activity reveals that compounds are highly active against the MCF-7 cell lines, even at low concentration. Among the synthesized compounds, a set of five (Group B) exhibits a nontoxic effect against normal cell lines even at high concentration, whereas the other set of six compounds (Group A) display a toxic effect. The drug likeliness and pharmacokinetic properties reveal that the compounds can be lead drug materials against breast cancer. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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