Effect of dialysate potassium and lactate on serum potassium and bicarbonate concentrations during daily hemodialysis at low dialysate flow rates

Autor: John K. Leypoldt, Michael A. Kraus, Bertrand L. Jaber, Eric D. Weinhandl, Allan J. Collins
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Nephrology, Vol 20, Iss 1, Pp 1-8 (2019)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-019-1450-7
Popis: Abstract Background Observational studies of hemodialysis patients treated thrice weekly have shown that serum and dialysate potassium and bicarbonate concentrations are associated with patient outcomes. The effect of more frequent hemodialysis on serum potassium and bicarbonate concentrations has rarely been studied, especially for treatments at low dialysate flow rate. Methods These post-hoc analyses evaluated data from patients who transferred from in-center hemodialysis (HD) to daily HD at low dialysate flow rates during the FREEDOM Study. The primary outcomes were the change in predialysis serum potassium and bicarbonate concentrations after transfer from in-center HD (mean during the last 3 months) to daily HD (mean during the first 3 months). Results After transfer from in-center HD to daily HD (data from 345 patients, 51 ± 15 years of age, mean ± standard deviation), predialysis serum potassium decreased (P
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