Clinical risk score for central precocious puberty among girls with precocious pubertal development: a cross sectional study

Autor: Jingyu You, Xianying Cheng, Xiaojing Li, Mingqing Li, Li Yao, Feihong Luo, Ruoqian Cheng, Li Xi, Jiangfeng Ye
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-021-00740-7
Popis: Abstract Background The gold standard for the diagnosis of central precocious puberty (CPP) is gonadotropin-releasing hormone (GnRH) or GnRH analogs (GnRHa) stimulation test. But the stimulation test is time-consuming and costly. Our objective was to develop a risk score model readily adoptable by clinicians and patients. Methods A cross-sectional study based on the electronic medical record system was conducted in the Children’s Hospital, Fudan University, Shanghai, China from January 2010 to August 2016. Patients with precocious puberty were randomly split into the training (n = 314) and validation (n = 313) sample. In the training sample, variables associated with CPP (P
Databáze: Directory of Open Access Journals