HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse

Autor: Emma Renman, Rifat Ekici, Mia Sundström, Kristina Lejon
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Autoimmunity, Vol 55, Iss 8, Pp 520-528 (2022)
Druh dokumentu: article
ISSN: 0891-6934
1607-842X
08916934
DOI: 10.1080/08916934.2022.2117307
Popis: B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.
Databáze: Directory of Open Access Journals
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