| Autor: |
Jian Xu, Yao Zhou, Ke Dong, Jun Gong, Wei Xiong, Xu Wang, Chun Gu, Xiang-yu Lu, De-pei Huang, Xu-dong Shen, Xue-ke She, Xiao-chen Zhao, Xiao-jiong Yu, Hao Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Asian Journal of Surgery, Vol 46, Iss 10, Pp 4371-4377 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1015-9584 |
| DOI: |
10.1016/j.asjsur.2023.02.056 |
| Popis: |
Objective: To explore the correlation between hepatocellular carcinoma (HCC) gene variation profile and clinical characteristics in Han nationality with HBV infection in Sichuan province. Methods: The clinical data and HCC tissues were obtained from the enrolled patients. Whole exome sequencing and bioinformatics analysis were performed on formalin-fixed and paraffin-embedded samples from HCC. Tumor mutational burden (TMB) was measured by an algorithm developed in-house. Results: Sixteen high-frequency mutated genes with differential expressions were identified by WES. SMG1 gene variation could be positively correlated with satellite lesions. AMY2B and RGPD4 gene mutation seemed to have a greater chance of vascular invasion. The patients with TATDN1 variation have bigger diameters and greater chances of vascular and microvascular invasion (all P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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