| Autor: |
Po-Han Wu, Wei-Li Hsu, Pei-Shiue Jason Tsai, Vin-Cent Wu, Han-Ju Tsai, Ya-Jane Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1746-6148 |
| DOI: |
10.1186/s12917-019-2048-9 |
| Popis: |
Abstract Background Neutrophil gelatinase-associated lipocalin (NGAL), a promising renal biomarker, can exists as a monomer, a dimer and/or in a NGAL/matrix metalloproteinase-9 (MMP-9) complex form when associated with different urinary diseases in humans and dogs. In this study, the presence of the various different molecular forms of NGAL in cat urine (uNGAL) was examined and whether these forms are correlated with different urinary diseases was explored. Results One hundred and fifty-nine urine samples from cats with various different diseases, including acute kidney injury (AKI, 22 cats), chronic kidney disease (CKD, 55 cats), pyuria (44 cats) and other non-renal and non-pyuria diseases (non-RP, 26 cats), as well as healthy animals (12 cats), were collected. The molecular forms of and concentrations of urinary NGAL in these cats were analyzed, and their uNGAL-to-creatinine ratio (UNCR) were determined. The cats with AKI had the highest UNCR (median: 2.92 × 10− 6), which was followed by pyuria (median: 1.43 × 10− 6) and CKD (median: 0.56 × 10− 6); all of the above were significantly higher than the healthy controls (median: 0.17 × 10− 6) (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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