Tetravalent neoglycoсonjugate based on the d-galactose for medicine purposes
| Autor: | A. I. Magasumova, E. D. Shuina, Yu. L. Sebyakin, U. A. Budanova, I. S. Shchelik |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Тонкие химические технологии, Vol 10, Iss 4, Pp 22-26 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2410-6593 2686-7575 |
| Popis: | Previously, the scheme of the preparation of a tetravalent neoglycoconjugate with the terminal residues of D-galactose and with a branching component based on D-galactose was carried out in our laboratory. It includes the synthesis of hydrophilic and hydrophobic components, the synthesis of the branching scaffold and its conjugation with a hydrophilic component. This article describes the optimization of the synthesis of 1-O-azidoethyl-β-D-galactopyronaside using the change of different parameters such as temperature, solvent and reaction time. The structure of obtained glycoconjugates has potential to be capable to anti-adhesion and target delivery to certain cell group. |
| Databáze: | Directory of Open Access Journals |
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