Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

Autor: Xi Yan, Zeping Zhao, Jeremy Weaver, Tao Sun, Jun-Won Yun, Carol A. Roneker, Fenghua Hu, Nicolai M. Doliba, Charles Chipley W. McCormick, Marko Z. Vatamaniuk, Xin Gen Lei
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Redox Biology, Vol 56, Iss , Pp 102457- (2022)
Druh dokumentu: article
ISSN: 2213-2317
DOI: 10.1016/j.redox.2022.102457
Popis: We previously reported a depletion of murine regenerating islet-derived protein 2 (REG2) in pancreatic islets of glutathione peroxidase-1 (Gpx1) overexpressing (OE) mice. The present study was to explore if and how the REG2 depletion contributed to an augmented glucose stimulated insulin secretion (GSIS) in OE islets. After we verified a consistent depletion (90%, p
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