A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone

Autor:	Bianca Diedericks, Anna-Mari Kok, Vusani Mandiwana, Namrita Lall
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	tuberculosis (TB) antimycobacterial cytotoxicity 7-methyljuglone poly-(lactide-co-glycolide) (PLGA) nanoparticle Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 16, Iss 2, p 216 (2024)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics16020216
Popis:	7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against Mycobacterium tuberculosis. Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound.
Databáze:	Directory of Open Access Journals
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