Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Autor: Yanis L. Tolstov, Alycia Knauer, Jian Guo Chen, Thomas W. Kensler, Lawrence A. Kingsley, Patrick S. Moore, Yuan Chang
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 17, Iss 8, Pp 1371-1380 (2011)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid1708.110079
Popis: Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody positive at initial enrollment. Of the 117 MCV-seronegative men, 31 subsequently seroconverted over a 4-year follow-up period, corresponding to a 6.6% annual conversion rate. MCV immunoglobulin G levels remained detectable up to 25 years after exposure. No signs, symptoms, or routine diagnostic test results were associated with MCV infection, and no correlation between HIV infection or AIDS progression and MCV infection was noted. An initial correlation between chronic hepatitis B virus infection and MCV prevalence could not be confirmed among MCV seroconverters or in studies of a second hepatitis B virus–hyperendemic cohort from Qidong, China. In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations.
Databáze: Directory of Open Access Journals
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