Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy
| Autor: | Hiroaki Tanaka, Shintaro Maki, Shoichi Magawa, Masafumi Nii, Kayo Tanaka, Kenji Ikemura, Kuniaki Toriyabe, Tomoaki Ikeda |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Medicina, Vol 55, Iss 10, p 708 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1010-660X 55100708 |
| DOI: | 10.3390/medicina55100708 |
| Popis: | Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow. Materials and Methods: We recruited five pregnant women with FGR or preeclampsia before administration of tadalafil, all of which were administered tadalafil (20 mg/day, once-daily dosing). The blood concentration of tadalafil was measured 1, 2, 4, 6, 8, and 24 h after administration, and uterine blood flow was measured before tadalafil administration and 2−4 and 20−24 h after. We then analyzed the correlation between tadalafil blood concentration and uterine artery blood flow. Results: The blood concentration of tadalafil correlated with uterine artery blood flow in pregnant women. The blood concentration of tadalafil and uterine artery blood flow decreased 5 h after administration of tadalafil. Conclusions: The blood concentration of tadalafil and uterine artery blood flow fluctuate in parallel, the latter was decreased by reduced blood concentration. Thus, a study of tadalafil administered twice a day in pregnant women will be needed to stabilize uterine artery blood flow. |
| Databáze: | Directory of Open Access Journals |
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