The Study of Apelin-13 for the Assessment of Endothelial Dysfunction in Prehypertension and Hypertension Patients
| Autor: | Balu Kanumuru, Tadi Santhi, Nutakki Sridevi, Singaswamy Srivani |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | International Journal of Scientific Research in Dental and Medical Sciences, Vol 5, Iss 2, Pp 61-65 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2676-5497 2676-5373 |
| DOI: | 10.30485/ijsrdms.2023.399061.1495 |
| Popis: | Background and aim: Hypertension is a leading global burden of deaths, coronary heart diseases, and stroke. Hypertension causes low-grade chronic systemic inflammation associated with endothelial dysfunction and vascular complications. The present study aimed to assess Apelin-13 levels in prehypertension and hypertension patients and find their association with oxidized low-density lipoprotein (LDL) and lipid profile.Material and methods: Sixty prehypertension and 60 hypertension with the age group of 35 to 50 years were selected, and 60 healthy age-matched subjects were selected as controls. Beckman Colter's fully automated analyzer carried out serum apelin-13 and oxidized LDL estimated by enzyme-linked immunosorbent assay (ELISA) and other routine investigations.Results: Apelin-13 levels were significantly increased in hypertensive patients compared to prehypertensive patients. A significant positive correlation was observed between apelin-13 and oxidized LDL and triglyceride levels. Further, there was no significance observed between other lipid profile parameters.Conclusions: Apelin-13 is a vital factor for assessing endothelial dysfunction in hypertensive patients. Reduction of apelin-13 may be beneficial in preventing vascular complications and coronary heart diseases in hypertensive patients. |
| Databáze: | Directory of Open Access Journals |
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