Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study

Autor: Pedro Maciel de Vasconcellos Ferreira, Marina de Castro Monteiro Franco Gomes, Ana Clara Speziali Menegazzi Almeida, Júlia Soares Cornélio, Thiago Jardim Arruda, Arnoldo Mafra, Marcelo Henrique Silva Nunes, Rafael Borges Salera, Raquel Fabiane Nogueira, Juliana Maria Braga Sclauser, Ana Paula Drummond-Lage, Bruno Almeida Rezende
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Head & Face Medicine, Vol 19, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1746-160X
DOI: 10.1186/s13005-023-00356-3
Popis: Abstract Background Due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, recently, Radiotherapy (RT) protocols requiring fewer sessions (hypofractionated) have been used to shorten RT treatment and minimize patient exposure to medical centers, and decrease the risk of SARS-CoV-2 infection. Methods This longitudinal, prospective, observational study aimed to compare the quality of life (QoL) and the incidence of oral mucositis and candidiasis in 66 patients with head and neck cancer (HNC) who undergo a hypofractionated RT protocol (GHipo), total of 55 Gy for 4 weeks, or a conventional RT protocol (GConv), total of 66 − 70 Gy for 6 − 7 weeks. Purpose To assess the incidence and severity of oral mucositis, the incidence of candidiasis, and QoL were evaluated using the World Health Organization scale, clinical evaluation, and the QLC-30 and H&N-35 questionnaires, respectively, at the beginning and the end of RT. Results The incidence of candidiasis did not show differences between the two groups. However, at the end of RT, mucositis had a higher incidence (p
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