An Experience of Donor Lymphocyte Infusion after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease

Autor: Tahereh Rostami, Azadeh Kiumarsi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Pediatric Reports, Vol 12, Iss 3, Pp 149-154 (2020)
Druh dokumentu: article
ISSN: 2036-7503
DOI: 10.3390/pediatric12030030
Popis: Allogeneic hematopoietic stem-cell transplantation is a well-known curative treatment for patients with chronic granulomatous disease. We present our experiment regarding ten patients with chronic granulomatous disease who underwent a reduced intensity conditioning regimen consisting of melfalan, fludarabine, and antithymocyte globulin. Donor lymphocyte infusion was used in three representative patients who developed mixed donor chimerism. After at least 2 years of median follow-up, 8 of the 10 patients are alive and well.
Databáze: Directory of Open Access Journals