Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion

Autor:	Jason L. Russell, Henry A. Spiller, Daniel D. Baker
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Medicine
Zdroj:	Case Reports in Medicine, Vol 2015 (2015)
Druh dokumentu:	article
ISSN:	1687-9627 1687-9635
DOI:	10.1155/2015/369707
Popis:	Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity.
Databáze:	Directory of Open Access Journals
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