Troponin T and Histological Characteristics of Rat Myocardial Infarction Induced by Isoproterenol
| Autor: | Sabaheta Hasić, Radivoj Jadrić, Emina Kiseljaković, Zakira Mornjaković, Mira Winterhalter-Jadrić |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Biomolecules & Biomedicine, Vol 7, Iss 3 (2007) |
| Druh dokumentu: | article |
| ISSN: | 2831-0896 2831-090X |
| DOI: | 10.17305/bjbms.2007.3046 |
| Popis: | In our investigation, we used short-time model of myocardial infarction of rats induced by high dose of isoproterenol (ISP). We investigated cardiac troponin T blood level (cTnT) and histological characteristics of rat myocardium. ISP, single, intraperitoneal dose 250 mg/kg was given to male, adult, Wistar rats (n=12). Rats were distributed depending on their body weight in subgroups: ISP I (BW 260-280g) and ISP II (BW 250-400g). Control group (n=9) was treated with intraperitoneal dose of 0,95% NaCl. Cardiac TnT was measured by electrochemiluminiscence (ECLA) sandwich immunoassay in rat serum 4 hours after ISP application. Rats’ hearts were dissected and examined by qualitative histological method (HE). Statistical significance was set at 0,05. There was significant difference in cTnT of ISP II (p=0,0001) vs. control and ISP I (p |
| Databáze: | Directory of Open Access Journals |
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