Clinical trials of stem cell-based therapies for pediatric diseases: a comprehensive analysis of trials registered on ClinicalTrials.gov and the ICTRP portal site

Autor: Yinwen Ji, Chuan Hu, Zuxing Chen, Ying Li, Jiayong Dai, Jin Zhang, Qiang Shu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 1757-6512
DOI: 10.1186/s13287-022-02973-2
Popis: Abstract Background Research on clinical trials that employ stem cells to treat children’s diseases is limited. The clinical trial registry database provides a unique window to us to get known about clinical trial researches with different statuses. However, few studies aimed to perform a comprehensive and thorough analysis of those registered trials in the aforementioned field based on ClinicalTrials.gov and the ICTRP portal site. Methods Our study covered the clinical researches about stem cell therapy enrolling subjects aged under 18 years old registered on ClinicalTrials.gov and WHO ICTRP before May 18, 2021. A cross-sectional study was implemented to comprehensively describe and analyze the included trials that met the criteria. Results were available on ClinicalTrials.gov, and publications related to the included trials were identified. All analyses were performed utilizing the SPSS 25.0 software. Results Eventually, 202 clinical trials were included and evaluated. The participant number of trials tended to be small; 71.3% were enrolled
Databáze: Directory of Open Access Journals
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