| Autor: |
Albert E. Schultze, William E. Alborn, Ronald K. Newton, Robert J. Konrad |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 46, Iss 8, Pp 1591-1595 (2005) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.C500010-JLR200 |
| Popis: |
Apolipoprotein A-V (apoA-V) first gained attention as a regulator of triglycerides through transgenic mouse studies. Furthermore, peroxisome proliferator-activated receptor α (PPARα) agonists such as fenofibrate increase apoA-V mRNA expression. Our group recently developed the first assay to quantitate serum apoA-V levels. Therefore, we sought to determine whether administration of a PPARα agonist would increase circulating apoA-V. Cynomolgus monkeys were dosed for 14 days with 0.3 mg/kg/day LY570977 l-lysine, a potent and selective PPARα agonist. Blood samples were drawn throughout the treatment period and after a 2 week washout. Administration of the PPARα agonist caused a 50% decrease in triglycerides that reversed at washout. Serum apoA-V concentrations increased 2-fold, correlated inversely with triglycerides, and were reversible at washout. The apoA-V/apoC-III ratio increased >2-fold, with this increase also reversible at washout.These data demonstrate for the first time that a PPARα agonist increases circulating apoA-V protein levels and the apoA-V/apoC-III ratio. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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