Follicle-stimulating hormone inhibits cervical cancer via NF-κB pathway

Autor: Shi X, Qiu S, Zhuang W, Wang C, Zhang S, Yuan N, Yuan F, Qiao Y
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: OncoTargets and Therapy, Vol Volume 11, Pp 8107-8115 (2018)
Druh dokumentu: article
ISSN: 1178-6930
Popis: Xi Shi,1,* Shiwei Qiu,1,* Wei Zhuang,1,* Caiji Wang,1 Shili Zhang,1 Na Yuan,1 Fukang Yuan,2 Yuehua Qiao1 1The Institute of Audiology and Speech Science of Xuzhou Medical College, Xuzhou 221002, People’s Republic of China; 2Department of Vascular Surgery of Xuzhou Central Hospital, Xuzhou Institute of Cardiovascular Disease, Xuzhou 221009, People’s Republic of China *These authors contributed equally to this work Background: Follicle-stimulating hormone (FSH) has multiple biological functions. It is currently considered that FSH can inhibit cervical cancer, and our aim was to explore the underlying molecular mechanisms. Materials and methods: An in vivo experiment using nude mice injected with HeLa cells was performed. Flow cytometry, western blotting, and real-time quantitative PCR analyses were done. Results: Twenty one days after injection of HeLa cells, the subcutaneous tumor mass was significantly lower (P
Databáze: Directory of Open Access Journals
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