Sixteen Years of Experience with the Treatment of Advanced Colorectal Cancer in Iran; A Report from Three Institutions

Autor: Hasan Jalaeikhoo, Ahmad Khajeh-Mehrizi, Mohammad Zokaasadi, Mohsen Rajaeinejad, Seied Asadollah Mousavi, Mohammad Vaezi, Hosein Kamranzadeh Fumani, Manoutchehr Keyhani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Middle East Journal of Digestive Diseases, Vol 10, Iss 3, Pp 160-168 (2018)
Druh dokumentu: article
ISSN: 2008-5230
2008-5249
DOI: 10.15171/mejdd.2018.105
Popis: BACKGROUND Colorectal cancer (CRC) is one of the most common cancers worldwide. Recently treatments of advanced CRC have been immensely improved. In this study we reported the current state of advanced CRC in Iran regarding treatment and outcomes from 2000 to 2016. METHODS 370 subjects with stage III or IV of the disease were included in this study. Pathological subtypes other than adenocarcinoma were excluded. Demographics and other relevant clinical data were collected. RESULTS Mean age at diagnosis was 55.4 ± 12.6 years. Significant differences regarding the age, sex, primary tumor complication and location, lymph node involvement, and tumor size were not detected between patients with stage III and IV. Overall survival rate at 5 years was 69.5% (95% confidence interval: 60.8% - 76.6%) and 21.73% (95% CI: 12.46% - 32.70%) for patients with stage III and IV, respectively. Analysis of prognostic factors revealed that tumor grade was an independent factor predicting poorer outcome (poorly differentiated vs. well or moderately differentiated). Furthermore, in stage IV of the disease, IVb subgroup was found to be associated with a poorer outcome compared with stage IVa. CONCLUSION Even with the acceptable survival rates and more effective treatments, it seems that clinicopathological characteristics have yet the most important prognostic effect in advanced CRC.
Databáze: Directory of Open Access Journals
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