Low nailfold capillary density in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: biomarker of clinical outcome?

Autor:	A. J. Smits, K. Isebia, C. Combee-Duffy, S. van der Wal, E. J. Nossent, A. Boonstra, A. Vonk-Noordegraaf, H. J. Bogaard, E. H. Serné
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Pulmonary arterial hypertension Pulmonary hypertension Chronic thrombo-embolic pulmonary hypertension Nailfold-capillaroscopy Microvascular Diagnosis Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-69017-y
Popis:	Abstract Nailfold capillary density is lower in patients with pulmonary arterial hypertension (PAH). It is unclear whether this observation signifies a unique systemic manifestation of PAH, or reflects microcirculatory dysfunction secondary to pulmonary hypertension (PH). Capillary density and loop dimensions were measured by nailfold-capillaroscopy (NC) in 30 PAH (23 idiopathic, or iPAH, 7 hereditary, or hPAH), 17 chronic thromboembolic PH (CTEPH) patients and 48 controls. NC-Measurements were repeated after pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) in CTEPH patients. We examined whether NC-measurements were related to markers of disease severity and predictive of time to clinical worsening (TTCW) as tested by univariate linear/logistic regression and cox-regression analysis, respectively. Capillary density was significantly lower in PAH (7.5 ± 1.1, p
Databáze:	Directory of Open Access Journals
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