Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage
| Autor: | Shahrzad Havakhah, Hamid R Sadeghnia, Mosa-Al-Reza Hajzadeh, Nama Mohammadian Roshan, Somayeh Shafiee, Hossein Hosseinzadeh, Narges Mohareri, Abolfazl Khajavi Rad |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Iranian Journal of Basic Medical Sciences, Vol 17, Iss 12, Pp 986-992 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2008-3866 2008-3874 |
| Popis: | Objective(s):There are a few previously reported studies about the effect of Nigella sativa oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI. Materials and Methods: IRI was induced by clamping of bilateral renal arteries for 40 min fallowed by reperfusion for 180 min. NSE was prepared in a Soxhlet extractor and administrated with doses of 150 mg/kg or 300 mg/kg at 1 hr before ischemia induction (P-150 and 300) or at the beginning of reperfusion phase (T-150 and 300), via jugular catheter intravenously. The kidneys were then removed and subjected to biochemical analysis, comet assay or histopathological examination. Results: The kidneys of untreated IRI rats had a higher histopathological score (P |
| Databáze: | Directory of Open Access Journals |
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